Million Dollar Bike Ride-CADASIL Fund
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  5/4/21 All Team CADASIL total funds raised! Amazing! Thank you supporters!  
Fundraising goal $50,000.00
Recent donations (8 donations)
Name DescendingX Amount
For Ritamarie and Madeline $100.00
Michele and Keith Osani
TerryAnn & Joe Maes $50.00
Mrs. Sharon Chapman
Coale Family $100.00
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Recent donations
#1 Team CADASIL 2021 Million Dollar Bike Ride Main Page Donations from other Team CADASIL pages reflected here

Team CADASIL is participating in the Million Dollar Bike Ride for the third time!
Again in 2021, cureCADASIL has partnered with Penn Medicine Orphan Disease Center to participate in the Million Dollar Bike Ride! This year the event will be virtual on June 12th due to Coronavirus concerns. In six years, the Million Dollar Bike Ride's 25+ teams have funded over $10 million in research grants on the rare diseases they represent. The Orphan Disease Center ensures that 100% of the funds raised goes towards these pilot grants, with no overhead taken out.

All donations to Team CADASIL will be matched, up to $30,000, by UPenn Orphan Disease Center to fund a new research grant for CADASIL. Last year, this event raised an astonishing $82,000 for a CADASIL specific research grant with your help!!

Our timeline again is short to reach our overall goal of raising $50,000 by June 12th . Support Team CADASIL and share this link with friends and family and through social media. Donate $5, $10, $25 - every gift matters!
Our Team needs you too!
****OUR AMAZING TEAM CADASIL PARTICIPANTS****

Kennedy Family -http://givingpages.upenn.edu/conquercadasilkennedy
Carney Family - http://givingpages.upenn.edu/TheCarneys
Peterson Family - http://givingpages.upenn.edu/rememberingEileen
de Lencastre Family - http://givingpages.upenn.edu/bikeinPhilly

Do you want to help?? Create a Penn Giving Page that will support Team CADASIL and the fund at Penn Med specifically for CADASIL research.
For directions on how to create a personalized Giving Page, please visit: https://www.milliondollarbikeride.org/fundraising-1
Questions? nmaurer@cureCADASIL.org
What is CADASIL?
CADASIL is a rare, autosomal dominant genetic disorder caused by a mutation of the NOTCH3 gene on the 19th chromosome. Hallmark symptoms of CADASIL may include: recurrent strokes, cognitive impairment, migraine with aura, and psychiatric disturbances. These symptoms are caused by damage to small blood vessels, especially those within the brain. The specific symptoms and severity of the disorder can vary greatly among affected individuals, even among members of the same family. Despite this variability, most individuals (approximately three out of four patients) experience recurrent stroke or transient ischemic attacks (TIAs), beginning at 40-50 years of age. CADASIL affects all races and both genders equally, each child of a parent with CADASIL has a 50% chance of having the disorder.

CADASIL is an acronym that stands for:
(C)erebral - relating to the brain
(A)utosomal (D)ominant - a form of inheritance in which one copy of an abnormal gene is necessary for the development of a disorder
(A)rteriopathy - disease of the arteries (blood vessels that carry blood away from the heart)
(S)ubcortical - relating to specific areas of the brain supplied by deep small blood vessels
(I)nfarcts - tissue loss in the brain caused by lack of blood flow to the brain, which occurs when circulation through the small arteries is severely reduced or interrupted
(L)eukoencephalopathy - lesions in the brain white matter caused by the disease and observed on MRI.

The diagnostic test for CADASIL was discovered in the early 2000s. Many individuals have been misdiagnosed with Multiple Sclerosis and other neurologic disorders.
Why We Need You!
The Penn Medicine Center for Orphan Disease Research hosts this event to raise money for research in rare diseases such as CADASIL, and they will MATCH EVERY DOLLAR DONATED!! (up to $30,000) Please consider donating to our cause and being a part of transformative research. 100% of your donation will go towards a new CADASIL research grant through UPenn!
  • Dominant rare disease impacting multiple generations of those diagnosed
  • Partnership with cureCADASIL Non-profit Organization
  • Support someone with CADASIL that you love
  • Rare diseases impact more people than cancer
  • 100% of your donation is tax-deductible
  • Give some amazing families hope
  • Support of one person can and does make a difference
Donation messages
Thanks to Kennedy family --For Ritamarie and Madeline
Our deepest condolences to the entire Kennedy Clan. We will miss seeing Mr. Bob in his convertible at camp. --Michele and Keith Osani
In Memory and Honor of Steve McGuinness --Mrs. Sharon Chapman
I can't wait to join Team CADASIL in the Million Dollar Bike Ride in person one day, but I will join virtually again this year :) Making this donation on Rare Disease Day in honor of my Mom, my CADASIL friends and family, and another amazing CADASIL research grant! Thank you --Ms. Sandra Talbird
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delrossi@upenn.edu | Anne Marie Del Rossi, Director, Data Services | 215.898.3062
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