The Penn Medicine Orphan Disease Center (ODC) will host the 12th Annual Million Dollar Bike Ride on Saturday, June 14, 2025 to raise money for rare disease research.

The Million Dollar Bike Ride brings over 600 cyclists and volunteers to Penn's campus to ride either 10, 32, or 72 miles starting in the city, and ranging across the Greater Philadelphia region. In eleven years, the MDBR's 30+ teams have raised over $22 million to fund research grants on the diseases they represent. The ODC ensures that 100% of the funds received goes towards these pilot grants.

If you would like to make a donation to our event, simply click on the red "donate" button to the left or the blue "donate now" button above, and then indicate in the "message" section of the donation page which Disease Team you would like to support with your donation. The registered teams are listed here:


Cohen Syndrome Champions
Cure CMD
LAM Foundation Easy Breathers
LGDA/LMI Riders
Love Never Sinks
Lulu's Crew
Pitt Hopkins Pedalers
Team CHIbra
SETBP1 Strong
Team CADASIL
Team Castleman
Team CDKL5 Riding for a Cure
Team CHM
Team FD/MAS
Team Gene Spotlight
Team MPS
Team NBIA Disorders
Team Telomere
Team ZC4H2
Team KCNT1
Riding for Ring14
Team Dup15q
Team CTNNB1
Project FAVA
HUWE1
KCNQ2 Cure Alliance
SATB2
UGDH Foundation
MEF2C


Or, if there is not a specific team you wish to support, we will distribute to our JumpStart team.