Susan K. Axler Foundation 2-PREVENT Translational Center of Excellence Fund
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Recent donations (29 donations)
Name DescendingX Amount
Gail and Bill Novotny $100.00
William & Nan Kent $50.00
Sylvia Finkel $100.00
Stablini $50.00
Roz and Ivan Stern $500.00
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Susan K. Axler Foundation for Breast Cancer Cures, Inc.

Susan Axler was a tireless advocate for research and advances in therapies leading to the cure of breast cancer. Sue battled metastatic breast cancer for 17 years during which time she volunteered, participated in major cancer grant review panels, attended conferences, and inspired many others to volunteer.

The Susan K. Axler Foundation, a 501(c)(3) established by her family within a year of her death in 2017, is primarily directing its efforts to Penn Medicine's 2-Prevent Translational Center of Excellence (TCE) at the Abramson Cancer Center of the University of Pennsylvania.

The mission of TCE is to work together as a multi-disciplinary team of Penn scientists and breast cancer clinicians to understand why some women have recurrence. This is accomplished through prediction, prevention, monitoring, detection, and treatment measures. The TCE aims to address one of the major challenges in breast cancer treatment: The high rate of relapse and late treatment effects among breast cancer survivors.

Approximately 30 percent of breast cancer patients ultimately relapse, and many more experience late effects of treatment or are diagnosed with a second cancer. Breast cancer research and treatment have long focused on a patient's original tumor as a guide to preventing relapse; however, research suggests that some recurrent cancers are different from the primary tumor and may respond better to different therapies. This has led millions of breast cancer survivors without meaningful measures to monitor and prevent recurrence in a more proactive way.

The TCE's Surmount Clinical Trial underway is a surveillance testing procedure to identify markers that indicate a higher risk of recurrence. Three recurrence prevention trials (Clever, Glacier, and Clear) are also underway with targeted therapies aimed at stopping the return of breast cancer for women who have in the past undergone treatment for primary breast cancer. For women with higher risk of recurrence, successful trial outcomes will lead to important cure outcomes.

The TCE is led by Lewis Chodosh, MD, PhD and Angela De Michele, MD, MSCE. The Abramson Cancer Center had more nationally recognized research and recurrent breast cancer in the basic sciences labs and in the clinic - than any other cancer center in the country. This makes Penn well positioned to address the challenges of breast cancer, recurrence and metastatic disease.
Jewelry, Jazz, and Just Dessert
On 6/12/2019, more than 70 of Sue's friends and family met to pay tribute to her memory and to support the newly-formed Susan K. Axler Foundation for Breast Cancer Cures. We learned about the latest advances in Penn Medicine's clinical trials, which are supported by the Foundation. Sue's Thursday Morning Book Club planned this event.

There was a wealth of donated jewelry to purchase to benefit the Foundation, friends to connect with to share Sue memories and stories all the while, toasting with glasses of bubbly and enjoying the delights from the bountiful and beautiful dessert spread. The desert trays from Whole Foods and LPQ were much appreciated! Sue's granddaughter Becca presided over the scarf-and-costume jewelry "Sue's Table", for those wishing a memento of Sue.

Joanne Bowes highlighted Sue as her personal inspiration in working as a patient advocate for clinical trials, and introduced our guest speaker, Dr. Angela DeMichele, co-leader of the Breast Cancer Translational Center of Excellence at the University of Pennsylvania. Sue worked with Dr. DeMichele on the 2PREVENT clinical trials, which were then explained by Dr. DeMichele in a condensed and very comprehensible short talk.

The clinical trials focus on targeting disseminating tumor cells that may remain in a patient's body after conventional breast cancer treatments of radiation and chemotherapy have been completed. Dr. DeMichele noted that, so far, the results of these Foundation supported trials have been encouraging and that she is grateful for the wonderful support that Sue's friends and family are providing. A brief question-and-answer period at the end of the talk touched on how this research relates to other types of cancer, and also the role of the placebo in clinical trials.

We raised more than $4,000 for the Penn Medicine Clinical Trials at the event, as well as learning about the latest advances in research. Sue, who loved education and chatting with her friends over great food, was certainly present with all of us that afternoon.

Every dollar donated (see Donate Now link on this page) goes to the TCE Clinical Trials as there are no administrative fees. If donating by check please make the check payable to Trustees of the University of Pennsylvania Medicine. In the check memo note Susan K. Axler Foundation. Mail to Michael Axler 200 W. Washington Sq. Apt 2706 Philadelphia Pa 19106.

    Donation messages
    Mike and Sue are always in my heart. I am a breast cancer survivor and Dr. Fox saved me. I only wish that Sue had survived even more years under his loving care. Love always, Cousin Sylvia --Sylvia Finkel
    From Fernando Arturo Benavides and Cheryl Phyllis Benavides --Fernando Arturo Benavides
    Sue is forever in our hearts. Breast cancer cures in our lifetime is the goal! Looking forward to this enlightening afternoon of Sue's favorite things! --Janis and David
    I'm so sorry we can't make it -- best wishes for a fabulous event to benefit such an important cause. I know that Sue would be so proud. --Ms. Pat Myers
    Sue was a wonderful person and experienced advocate. I'm glad that our paths crossed in the advocacy world and grateful that her family has set up this fund to continue her legacy in supporting breast cancer research and clinical trials. --Joan Mancuso

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