The RASopathies are a group of genetic syndromes caused by mutations in genes on the Ras-MAPK pathway. These syndromes, which include: Noonan (NS), cardio-facio-cutaneous (CFC), Costello (CS), Neurofibromatosis type 1 (NF1), and LEOPARD/NSML, share many clinical features, including developmental delay, gastrointestinal difficulties, skeletal abnormalities, hematologic abnormalities, and growth delay.